Pdx1 Expression in Pancreatic Precursor Lesions and Neoplasms
نویسندگان
چکیده
منابع مشابه
P53 expression in invasive pancreatic adenocarcinoma and precursor lesions.
Patients with pancreatic adenocarcinoma are known to have a high mortality rate. The 5-year survival rate still remains low even now compared to that of the 1960's despite new advances in management including surgery, chemotherapy, pathological classification and molecular diagnostic technologies. Precursors to invasive pancreatic adenocarcinoma have been identified in the last ten years that i...
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Differentiation of early foregut endoderm into pancreatic endocrine and exocrine cells depends on a cascade of gene activation events controlled by various transcription factors. Prior in vitro analysis has suggested that the forkhead/winged helix transcription factor Foxa2 (formerly HNF-3 ) is a major upstream regulator of Pdx1, a homeobox gene essential for pancreatic development. Pdx1 is als...
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Pancreatic adenocarcinoma displays a variety of molecular changes that evolve exponentially with time and lead cancer cells not only to survive, but also to invade the surrounding tissues and metastasise to distant sites. These changes include: genetic alterations in oncogenes and cancer suppressor genes; changes in the cell cycle and pathways leading to apoptosis; and also changes in epithelia...
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The promigratory molecule L1CAM is overexpressed in various tumors, often representing an unfavorable prognostic marker. Recently, we identified L1CAM expression in pancreatic ductal adenocarcinoma (PDAC) cells accounting for chemoresistance and increased cell migration. Thus, the present study aims at further elucidating the role of L1CAM in a larger cohort of PDAC specimens including precurso...
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Introduction Intraductal papillary mucinous neoplasms (IPMNs) are a group of exocrine mucin-producing tumors, diagnosed at a mean age of 60 years, with a male prevalence [1]. Improvements in imaging techniques have led to an increasing incidental detection of IPMNs: the prevalence of incidental cystic pancreatic lesions can be observed in up to 19.6% of imaging studies [2]. Three types of IPMNs...
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ژورنال
عنوان ژورنال: Applied Immunohistochemistry & Molecular Morphology
سال: 2011
ISSN: 1541-2016
DOI: 10.1097/pai.0b013e318206d958